Therapeutic management of stroke to prevent secondary events in Literature review

Therapeutic management of stroke to prevent secondary events in patients who have experienced an ischaemic stroke or transient ischaemic attack (TIA) - Literature review Example ever posited that duration of manifestation of symptoms is a major issue in ITA as in ITA, the symptoms are only kindly to be the same as what is seen in stroke in the first 24 hours or less. Writing specifically on the pathophysiology of ITA and its clinical manifestation, Iadecola and Gorelick (2012) stressed that the primary pathophysiology of the disease is the underlying heart or blood vessel disease, which manifests in several forms, including atherosclerotic vascular disease. Atherosclerotic vascular diseases have been associated with ischaemic stroke and actually considered a major cause of ischaemic stroke or transient ischaemic attack (ITA) (Rothwell, 2011). This is because the onset of atherosclerotic vascular diseases has actually been linked with the occurrence of occlusive lesions which take place in major intracranial and extracranial arteries. Meanwhile, any form of inhabitation of supply of blood to the heart could be associated with possible breakdown in the active functioning of the brain (Adams et al., 2008). Rashid, Leonardi-Bee and Bath (2013) noted that with the onset of atherosclerotic vascular disease which is the primary pathophysiology of both stroke and ITA, the damage to lesions resulting from occlusive lesions bring about further secondary manifestations, necessary for diagnosis. As this occlusive lesions, which is a form of severely stenotic lesions occur at the major intracranial and extracranial arteries, they lead to the narrowing of small penetrating arteries of the brain and thus the cause or onset of secondary events in patients with TIA (Fayad, 2006). In relation to the current research problem, Bornstein, Silvestrelli, Caso and Parnetti (2012) found that where there pathophysiology and clinical manifestation shows clear possibility of ITA, it is very important that immediate management steps are taken to avert further secondary events, leading to stroke. This is because there is only a thin line from the transition point from